LOS ANGELES, May eighteen (Xinhua) — Individuals who are vaccinated with the smallpox vaccine called “vaccinia” might have higher resistance against HIV infection, a new research finds.
The idea stems from current work by scientists at the University of California, Los Angeles, and George Mason College in Manassas, Va. The results were published in the May issue of Immunology, a journal of the British Healthcare Council (BMC).C).
If true, the finding could link the fast, late 20th-century spread of HIV to the simultaneous vanquishing of smallpox disease and the removal of the smallpox vaccine from worldwide distribution, specialists say.
The vaccine for smallpox was steadily eliminated from use between the nineteen fifties and the 1970s, subsequent global elimination of the disease.
“There have been a number of proposed explanations for the fast spread of HIV in Africa,” Dr. Raymond Weinstein of George Mason University stated in a news launch. These include “wars, the reuse of unsterilized needles and the contamination of early batches of polio vaccine,” he stated.
“Nevertheless, all of these have been both disproved or do not sufficiently clarify the behavior of the HIV pandemic,” he stated. ” Our discovering that prior immunization with vaccinia virus may offer an person with some degree of protection to subsequent HIV infection suggests that the withdrawal of this kind of vaccination may be a partial clarification.”
The study authors noted that the vaccine for smallpox was steadily removed from use in between the 1950s and the seventies, following global elimination of the illness.
They point out that HIV began spreading quicker in more or less the exact same time frame.
To get a nearer look at how the two occurrences might be related, the researchers analyzed the conduct of white blood cells sampled from patients lately immunized with the smallpox vaccine.
They discovered that after publicity to HIV, cells from immunized people had been 5 occasions less likely to allow for HIV replication than the same cells taken from non-immunized sufferers.
The research team theorized that administration of the smallpox vaccine may set off long-term modifications in the immune method that guard towards HIV infection. They additional highlighted a certain receptor on the surface of white blood cells — known as “CCR5” — as one feasible target of this kind of a beneficial alter.
But the scientists said the outcomes are preliminary and further studies are required.
“While these results are extremely fascinating and ideally might direct to a new weapon towards the HIV pandemic, they are extremely preliminary and it is significantly too soon to recommend the common use of vaccinia immunization for combating HIV,” said Weinstein.
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